Evaluation of the mutagenic potential of Cochlospermum regium in Drosophila melanogaster male germ cells

AUTOR(ES)

Nunes, Wanderlene Blanco, Carvalho, Salvador de

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

2003-12

RESUMO

During the last few decades the search for medical treatments based on alternative medicine has increased significantly, making knowledge of the plants commonly used as folk medicines extremely important. The plant Cochlospermum regium, a member of the Cochlospermaceae found in the Brazilian cerrado (a type of savanna), is known to have high depurative activity and to be effective not only in treating skin problems such as pimples, boils and blotches but also in curing gastritis and ulcers. We prepared aqueous extracts using 13, 19 and 25 gL-1 of dried C. regium root and investigated these extracts for possible mutagenic effects on Drosophila melanogaster germ cells. Mutagenesis was assessed using the ring-X loss (RXL) test which can detect chromosome mosaicism, partial loss of the ring X chromosome and chromosome non-disjunction. Our results showed that at the concentrations tested C. regium extracts did not induce ring-X loss in D. melanogaster.

Documentos Relacionados

• Maternal exposure to Cochlospermum regium: a toxicological evaluation
• Dose Rate Effects in the Developing Germ Cells of Male Drosophila
• Heterochromatic Recombination in Germ Cells of DROSOPHILA MELANOGASTER Females
• Phenolic derivatives and other chemical compounds from Cochlospermum regium
• Drosophila Melanogaster Male Germ Line-Specific Transcripts with Autosomal and Y-Linked Genes