Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia
AUTOR(ES)
Cáceres, Diego H., Zuluaga, Alejandra, Tabares, Ángela M., Chiller, Tom, González, Ángel, Gómez, Beatriz L.
FONTE
Rev. Inst. Med. trop. S. Paulo
DATA DE PUBLICAÇÃO
21/12/2017
RESUMO
ABSTRACT A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.
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