Estudos biológico, imunológico e genético de amostras do vírus da raiva isoladas de morcegos no Estado do Rio de Janeiro - Sudeste, Brasil / Biological, immunological and genetic studies of rabies virus samples isolated from bats in Rio de Janeiro State - Southeast, Brazil

AUTOR(ES)

Carla da Silva Mota

DATA DE PUBLICAÇÃO

2008

RESUMO

In the present study we analyzed the biological behavior in mice of 10 rabies virus samples isolated from haematophagous and non-haematophagous bats in Rio de Janeiro State, its genetic characterization from genes N and G, and we also studied the response of mice vaccinated with cell culture rabies vaccine, produced with the Pitman-Moore strain, after viral challenge with bat rabies virus samples. Viral passages in mice resulted in reduced incubation period and high virus titrers. The vaccine used conferred protection in more than 80% of the mice vaccinated with 1:15 vaccine dilution, after viral challenge. N gene genetic analysis divided the samples in haematophagous bat strains and insectivorous bat strains, with phylogenetic differences between samples isolated in Northeast Region and those isolated in the Metropolitan and South Regions of Rio de Janeiro State. The substitution of an aspartic acid to a glutamic acid found in the position 118 of G gene genetic characterization from samples 704/97 and 151/98 seems to be related to viral antigenicity. There were no time-related genetic differences between the studied samples.

ASSUNTO(S)

rabies vaccine filogenia morcegos vírus da raiva phylogeny raiva vacina anti-rábica bats rabies rabies virus

Documentos Relacionados

• Caracterização biológica, antigência e genética de amostras de vírus da raiva isoladas de animais domésticos e de seres humanos no Estado do Maranhão
• Genetic characterization of rabies viruses isolated from bats. Evaluation of the pathogenicity and cross protection in mice
• Estudo antigênico de amostras do vírus da raiva isoladas no Rio Grande do Sul
• Mercury Concentrations in Bulk Atmospheric Deposition over the Coast of Rio de Janeiro, Southeast, Brazil
• Morcegos (Mammalia, Chiroptera) da Reserva Rio das Pedras, Rio de Janeiro, Sudeste do Brasil