Estudo neuroquímico do núcleo pré-mamilar ventral nos animais submissos durante os encontros agonísticos sociais. / Neurochemic study of the premammillary ventralis nucleus on submissive animals during social agonistic encounters.

AUTOR(ES)

Flavia Venetucci Gouveia

DATA DE PUBLICAÇÃO

2009

RESUMO

Aggressive behavior occurs when the interests of one or more individuals conflict. Territory is one of these interests, and the resident intruder paradigm is widely used to observe the expression of social agonistic behaviors. The dominance behavior has been studied under several views and it was shown that it can be raised by the presence of the female, its olfactory clues and by the sexual behavior. In the hypothalamus there is the premammillary ventralis nucleus (PMv) connected to a sexual dimorphic system and related to reproduction and agonistic behaviors. This nucleus was suggested as being involved in the modulation of aggressive behavior, and PMvs neuropeptides can have a direct relation with the expression of those agonistic behaviors. Males exposed to females olfactory clues show an increase in the expression of CART (C Cocaine and Amphetamine Regulated Transcript) in the PMv. Nitric oxide synthase (NOS) knockout animals show increased aggression. In the present investigation, using in situ hybridization we studied the expression of the mRNA of CART and NOS on intruders exposed to the resident-intruder paradigm. Two experimental groups were examined: one with sexual experience before the agonistic encounter and other naïve. It was observed increased expression of CART in the PMv in the sexual-experienced intruder. More, these animals behaved differently from naive intruders, and did not display submissive postures and start searching for dominance. Sexual experienced intruders presented increased expression of CART, but not NOS, mRNA. Thus, suggesting that the sexual experience is related to an increase in CART expression in the PMv and possibly with the lost of submissive behavior and increased search for dominance status.

ASSUNTO(S)

cocaine Óxido nítrico neurochemistry of animal neuroquímica de animal aggressive behavior cocaína comportamento agressivo nitric oxide hypothalamus hipotálamo

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