Estudo histolÃgico e morfomÃtrico do disco epifisÃrio de ratos neonatos tratados com fluoxetina

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The selective inhibitors of the re-uptake of the serotonin acts increasing the availability of this neurotransmitter in the synaptic cleft. Recent studies demonstrated the presence of receptors of serotonin in bone cells, suggesting the participation of this substance in the bone metabolism. The aim of this study is to verify the effects of the use of fluoxetine, a potent inhibitor of the selective re-uptake of the serotonin, on the growth of neonate mice and evaluate the possible morphologic and morphometric alterations on epiphyseal disc of the femur of these animals. 9 male albino mice Wistar aged 1 day were divided into two groups: control (n=3) and treated (n=6). The treated group received, daily, a subcutaneous injection with flouxetine (10mg/Kg em10μl/g) and the control group received saline solution 0,9 % of NaCl in the volume of 10μl/g. The body mass of the animals was verified daily. In the twenty-second day the animals were sacrified, the right femurs were collected, weighed, processed by the conventional histologic technique and analysed by light microscopy. The morphometric analysis of epiphyseal disc was realized to evaluate its section area, total thickness, thickness of rest zones, serial and hypertrophic and verification of the morphology of bone tissue. The results demonstrated that the treated group showed ponderous growth, body and femural weight inferior than the control group (p<0,05), as in the section area, There was no difference significant in the total thickness, and in the rest zones, serial and hypertrophic. Based on these results, the study concluded that the use of fluoxetine in growing mice provokes decrease of body and femural weight, decrease of ponderous growth and decrease of the section area of epiphyseal disc. The morphologic alterations suggest that fluoxetine play a role in the chondrocytes metabolism and bone formation

ASSUNTO(S)

anatomia patologica e patologia clinica crescimento serotonin serotonina disco epifisÃrio fluoxetina fluoxetine growth epiphyseal disc

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