Estudo da resistência de D. radiodurans à ação combinada de radiações ionizantes com campos elétricos ou magnéticos exógenos. / Study of resistance of D. radiodurans to the combined action of ionizing radiation with an electric or magnetic fields exogenous.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

05/08/2011

RESUMO

Several strategies have been worked out toward the enhancement of cellular radiosensibility, as the use of exogenous fields. In gamma irradiation D. radiodurans exhibited repairing shoulders of 2 and 8 kGy at the exponential and stationary phases, respectively. When gamma irradiations were combined with expositions to the electric field the repairing shoulders were reduced to 1 and 4 kGy at the exponential and stationary phases, respectively. Radioresistance was similar in both growing phases when the number of cells were approximately equalized in these two processes. On the other hand, when gamma irradiations were combined with expositions to the magnetic field the repairing shoulders were reduced to 4 and 6 kGy at the exponential and stationary phases, respectively. In irradiations with electron beams the repairing shoulder at the exponential phase was totally depleted, while at the stationary phase it was only 1 kGy. The findings of this work revealed new and important information on the radioresistance of D. radiodurans, while providing hints to the improvement of radiotherapy protocols in association with exogenous physical agents.

ASSUNTO(S)

biofísica biophysics campo eletromagnético dna dna electromagnetic field ionizing radiation radiação ionizante radiação ultravioleta radioterapia radiotherapy ultraviolet radiation

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