Estudo clinico-epidemiologico das infecções fungicas em receptores de transplante de medula ossea no Hospital das Clinicas na Universidade Estadual de Campinas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2001

RESUMO

Bone marrow transplant (BMT) recipients are at high risk for developing invasive fungal infections. Deep and prolonged immunosupression have been associated conditions to increase the number of invasive fungal infections in this population. The study of the local and specific epidemiology of these immunosuppressive patients has been an important issue for the treatment and application of preventive measures to reduce the risk of infections. The aim of this study was to evaluate the epidemiology of fungal infections in patients hospitalized in the BMT unit of the Hospital das Clínicas-UNICAMP. Diagnose of invasive fungal infections were made according to the EORTCINIAID criteria. One hundred and fifteen BMT patients, 91 allogenic and 24 autologous recipients were evaluated. Fifteen invasive fungal infections were detected and 8 (53.3%) had microbiological identification of the pathogens. Fungemia (n=8) and sinusitis (n=4) were the most prevalent funga! infections in our study. Five (62.5%) invasive fungal infections were caused by Candida spp. (C. parapsilosis=3) and two (25.0%) by Fusarium sp. Fifty-two (45.2%) patients had fungal colonization. Fungal colonization was more frequent in allogeneic BMT recipients (52.7%) than in autologous recipients (16.7%) (p=O.003). Independent risk factors for invasive fungal infections in allogeneic recipients, identified by multivariate analysis, were prolonged neutropenia (p<0.001) and total body irradiation in the conditioning regimen (P=O.021).The attributable mortality due to fungal infection was 20.0%. There was no difference in survival between patients with or without deep fungal infections (P=O.173)

ASSUNTO(S)

epidemiologia infecções oportunistas celulas da medula ossea transplante de orgãos tecidos etc

ACESSO AO ARTIGO

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