Estado funcional de fagócitos após a exposição de ratos ao formaldeído: relevância para a inflamação alérgica pulmonar. / Functional status of phagocytes after rat formaldehyde exposure: relevance for allergic lung inflammation.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Formaldehyde (FA) is an ambiental pollutant generated in industry and by burning of tobacco, alcohol, gasoline and LPG. As an airways irritant agent, the exposure to it may affect the modulation of allergic lung inflammation (ALI) triggered by unrelated antigens. We studied the functional activity of lung phagocytes and bone marrow cells from male Wistar rats previously subjected to FA inhalation (1%, 90 min/day, 3 days) and then subjected to ALI (ovalbumin sensitized and challenged), as well as the expression of adhesion molecules. Supernatants of lung explants, lung phagocytes and bone marrow cells were collected after 1, 4 or 24 h upon or not LPS or PMA stimulation. After FA inhalation, ALI increased NO2, H2O2, LTB4, TXB2, PGE2, IL-1b, TNF-a and decreased IL-10 in the lung, whereas enhanced NO2 e PGE2 and reduced H2O2, LTB4, TXB2, IL-1b and IL-10 in bone marrow cells. The interaction FA/OVA decreased the expression of ICAM-1, VCAM-1 e PECAM-1. In conclusion, FA significantly alters the functional activity of phagocytes involved with asthma induction.

ASSUNTO(S)

phagocytes fagócitos rats formaldeído inflamação asma asthma formaldehyde inflammation ratos inflammatory mediators mediadores inflamatórios

ACESSO AO ARTIGO

Documentos Relacionados