Epistasis and Its Contribution to Genetic Variance Components

AUTOR(ES)

Cheverud, J. M.

RESUMO

We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values. This parameterization leads to statistical tests for epistasis given estimates of two-locus genotypic values such as can be obtained from quantitative trait locus studies. The contributions of epistasis to the additive, dominance and interaction genetic variances are specified. Epistasis can make substantial contributions to each of these variance components. This parameterization of epistasis allows general consideration of the role of epistasis in evolution by defining its contribution to the additive genetic variance.

Documentos Relacionados

• The Genetic Variance for Viability and Its Components in a Local Population of DROSOPHILA MELANOGASTER
• Components of Genetic Variance in the Cultivated Strawberry
• Analysis of Conditional Genetic Effects and Variance Components in Developmental Genetics
• Mutator Factors and Genetic Variance Components of Viability in DROSOPHILA MELANOGASTER
• Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.