Eosinophilic myelodysplasia transforming to acute lymphoblastic leukaemia.
AUTOR(ES)
Follows, G A
RESUMO
A 43 year old male presented with a marked eosinophilia and associated systemic symptoms. A diagnosis of myelodysplasia was made on the basis of bone marrow morphology and karyotype. Over a 12 month period the disease transformed into acute lymphoblastic leukaemia, confirmed by flow cytometry, cytochemistry, and immunohistochemistry. Karyotyping was abnormal with 5q- and -7 which persisted from diagnosis through to blastic transformation. He died following initial induction chemotherapy. Eosinophilic myelodysplasia is an uncommon condition in haematological practice and no previous report of lymphoblastic transformation has been found.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1023079Documentos Relacionados
- Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia.
- Bone marrow fibrosis in childhood acute lymphoblastic leukaemia.
- Measles encephalitis during immunosuppressive treatment for acute lymphoblastic leukaemia.
- Morphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
- Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukaemia.
