Ensaio clínico randomizado para avaliação do efeito otoprotetor do extrato de Ginkgo Biloba, por meio das emissões otoacústicas por produto de distorção, em pacientes sob tratamento com cisplatina

AUTOR(ES)

Mirela Alves Dias

DATA DE PUBLICAÇÃO

2008

RESUMO

The ototoxicity is an alteration caused by drugs that compromises the auditory and vestibular functions. The cisplatin (CDDP) is a potent antineoplastic agent used for the treatment of cancer in both adults and children although it has several side effects. The cisplatin ototoxicity is a dose-limiting condition. Current opinion is that cisplatin ototoxicity occurs due to alterations in the antioxidant system of the outer hair cells (OHC) of the cochlea. Because this, different antioxidant drugs have been tested to evaluate the potential otoprotector effect when combined with cisplatin. The distortionproduct otoacoustic emission (DPOAE) has been showed to be a sensitive test for diagnosis of OHC injury and has been used for monitoring treatment with ototoxic drugs. Our proposal was to evaluate, using DPOAE test, the action of ginkgo biloba extract (EGB761), which has a known antioxidant property, as a possible otoprotector against cisplatin induced hearing loss. The study was conducted on individuals that would begin cisplatin treatment. They were randomized and allocated in two groups: Control group (CG) (n =07) receiving placebo plus CDDP and Study group (SG) receiving EGB761 (240mg/day) plus CDDP. Both groups were guided to ingest the drugs before first cisplatin dose. They were treated and followed up for approximately ninety days. The maximum cumulative cisplatin dosage was 300mg/m2. Comparisons were made between baseline measurements and those records after maximum cumulative cisplatin dosage. The GC showed smaller DPOAE mean values amplitudes and smaller DPOAE/noise. The SG did not show changes. We conclude that these results demonstrate that EGB761, because of their antioxidant properties, showed potential otoprotector effect against cisplatin ototoxicity in patients receiving cisplatin therapy.

ASSUNTO(S)

emissão otoacústica por produto de distorção ginkgo biloba ginkgo biloba distortion-product otoacoustic emission cisplatin cisplatina otoprotection ototoxicidade otoproteção ciencias da saude ototoxicity

Documentos Relacionados

• Análise das emissões otoacústicas evocadas por produto de distorção em neonatos prematuros
• Emissões otoacústicas evocadas por produto de distorção em indivíduos com audição normal
• Estudo das emissões otoacústicas por produto de distorção durante a hipotermia em humanos
• Curva de crescimento das emissões otoacústicas produto de distorção em neonatos.
• Emissões otoacústicas evocadas transientes e por produto de distorção em escolares