Effects of vancomycin on renal function in rats.
AUTOR(ES)
Aronoff, G R
RESUMO
To assess the effects of vancomycin on the kidney, we gave rats doses of 10, 50, 100, 200, and 400 mg/kg per day. Creatinine clearance and urine protein excretion did not differ significantly from the control values. Urine osmolality was unchanged. Mild histological changes occurred in rats given the highest dose. We conclude that although histopathological changes occurred at high doses, vancomycin does not alter renal function in rats.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=181415Documentos Relacionados
- Effects of daptomycin and vancomycin on tobramycin nephrotoxicity in rats.
- Central and peripheral effects of the peptide ANF on renal function and blood pressure in hypertensive rats.
- Measurement of renal function in unrestrained conscious rats.
- Altered renal function in chronically hyperprolactinaemic rats.
- Effects of enoxacin on renal and metabolic clearance of theophylline in rats.
