Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model
AUTOR(ES)
Özer, Taha, Aktas, Alper, Baris, Emre, Çelik, Hakan Hamdi, Vatansever, Alper
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2017-09
RESUMO
Abstract Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.
Documentos Relacionados
- Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis.
- Effects of morphine on corneal sensitivity and epithelial wound healing.
- To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
- Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs
- Supplemental vitamin A prevents the acute radiation-induced defect in wound healing.