Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers
AUTOR(ES)
Bigger, J. Thomas
RESUMO
Preparations of right ventricular papillary muscle and false tendon (Purkinje fiber) were obtained from dog hearts, placed in a bath perfused with Tyrode solution, and observed both under control conditions and during exposure to lidocaine in concentrations from 1 × 10-7 to 5 × 10-4 mole/liter. Transmembrane voltages were recorded from both ventricular muscle (VM) and Purkinje fibers (PF) of spontaneously beating and electrically driven preparations. Low concentrations (1 × 10-6 and 1 × 10-5 mole/liter) attenuated or abolished phase 4 (diastolic) depolarization and spontaneous firing in PF without decreasing their diastolic excitability. Concentrations of 1 × 10-5 mole/liter produced maximal shortening of both action potential duration (APD) and effective refractory period (ERP) and made the ERP long relative to APD; the latter alteration was more prominent in VM. At concentrations ≤ 1 × 10-5 mole/liter, lidocaine either caused a slight increase or no change in peak maximum rate of phase 0 depolarization (Vmax) and membrane responsiveness, the relationship between transmembrane activation voltage (MAV) and Vmax of the resultant action potential; these concentrations had no significant effect on resting potential (RP) in VM, maximal diastolic transmembrane voltage (DTMVmax) in PF, or action potential amplitude in either fiber type.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=322445Documentos Relacionados
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