Effect of fatty acids on action of polyene antibiotics.
AUTOR(ES)
Iannitelli, R C
RESUMO
Fatty acids cause a decrease in the absorption spectra of the antifungal polyene macrolide antibiotics nystatin, filipin, candicidin, and amphotericin B. For nystatin, filipin, and candicidin, this decrease in absorption could be correlated with the activity of the fatty acids in protecting the yeast Saccharomyces cerevisiae against the action of these antibiotics. With amphotericin B a correlation was observed between the decrease in absorption caused by certain derivatives of fatty acids and the protective action of these derivatives against the activity of amphotericin B on yeast. It is concluded that, like the sterols, fatty acids also interact with the polyene antibiotics and thereby reduce their effective concentrations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283888Documentos Relacionados
- Chemistry and biology of the polyene macrolide antibiotics.
- Chemistry and biology of the polyene macrolide antibiotics.
- Potentiation of antiviral activity of acyclovir by polyene macrolide antibiotics.
- EFFECT OF POLYENE ANTIBIOTICS ON PROTOPLASTS OF NEUROSPORA CRASSA1
- Cholesterol requirement of mycoplasmas as determined by microtiter test using polyene antibiotics.
