Effect of disodium cromoglycate (Intal) on sputum protein composition

AUTOR(ES)

Heilpern, Sandra

RESUMO

The protein content in the sputum of nine patients with asthma was compared with that in 11 non-asthmatic patients by a method of gel electrophoresis. It was found that the albumin content was significantly higher in the sputum of the asthmatics than of the non-asthmatics (P<0·01). A further 11 asthmatic patients who were taking disodium cromoglycate (Intal) as part of their treatment had sputum albumin levels indistinguishable from the non-asthmatics. When patients with asthma were then studied serially, before and after disodium cromoglycate therapy, the albumin content returned to non-asthmatic levels within two days of starting treatment. It is suggested that disodium cromoglycate has a previously unrecognized action in altering sputum proteins.

Documentos Relacionados

• Protective effect of disodium cromoglycate on rat peritoneal mast cells
• Hypoxia and lung mast cells: influence of disodium cromoglycate.
• Effect of atropine on sputum production.
• Long term study of the effect of sodium cromoglycate on non-specific bronchial hyperresponsiveness.
• Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis