Effect of collagen sponge and fibrin glue on bone repair
AUTOR(ES)
SANTOS, Thiago de Santana, ABUNA, Rodrigo Paolo Flores, ALMEIDA, Adriana Luisa Gonçalves de, BELOTI, Marcio Mateus, ROSA, Adalberto Luiz
FONTE
J. Appl. Oral Sci.
DATA DE PUBLICAÇÃO
2015-12
RESUMO
ABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
Documentos Relacionados
- Endaural extracranial repair for cerebrospinal otorrhoea with human fibrin glue: technical note.
- Effect of snake venom derived fibrin glue on the tendon healing in dogs: clinical and biomechanical study
- Effect of fibrin glue derived from snake venom on the viability of autogenous split-thickness skin graft
- Effect of Experimental Chronic Renal Insufficiency on Bone Mineral and Collagen Maturation
- Comparison of platelet rich plasma versus fibrin glue on colonic anastomoses in rats