Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation.

AUTOR(ES)

Gollapudi, S V

RESUMO

Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.

Documentos Relacionados

• Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy
• Effects of moxalactam and cefuroxime on mitogen-stimulated human mononuclear leukocytes.
• Prostaglandin Suppression of Mitogen-Stimulated Lymphocytes In Vitro: CHANGES WITH MITOGEN DOSE AND PREINCUBATION
• Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.
• Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction.