Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
AUTOR(ES)
Baracho, Nilo César do Vale, Monteiro, Natália Fechus, Borges, Manuela Guedes, Arguelho, Raíssa Robles de Moura
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2016-08
RESUMO
ABSTRACT PURPOSE: To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease. METHODS: Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control): distilled water. Group 2 (Azuki): Vigna angularis 5% aqueous extract. Group 3 (Treatment): 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days. RESULTS: The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group. CONCLUSION: Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
Documentos Relacionados
- Effect of chronic ethanol consumption in female rats subjected to experimental sepsis
- Considerations about an experimental model of chronic metabolic acidosis in rats
- Model of experimental chronic osteomyelitis in rats.
- Effects of grape seed extract on periodontal disease: an experimental study in rats
- Characterization of an experimental model of progressive renal disease in rats