Efeitos do óleo essencial de Croton sonderianus Muell. Arg. sobre a contratilidade do músculo liso traqueal de ratos. / Effects of essential oil of Croton sonderianus Muell. Arg. on the contractility of tracheal smooth muscle of rats.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

06/02/2007

RESUMO

Croton sonderianus is a plant found in Ceara State used in folk medicine as antispasmodic. Previous studies demonstrated that the essential oil of other specimens of Croton gender have relaxing effects on tracheal smooth muscle. This study aimed to characterize the effects of Croton sonderianus essential oil (EOCs) on tracheal smooth muscle of rats and investigate the role of epithelium in this effect. Wistar rats tracheal rings with and without epithelium were used. The rings were placed in tissue chambers containing modified Tyrode solution (TM) at 37o, pH=7,4, bubbled with air. The mechanical responses in trachea were isometrically recorded with a force transducer and polyghaph. Two different EOCs samples were used, EOCs 21 and EOCs 13. The major constituents of EOCs 21 were spathulenol (18,32%), -caryophyllene (14,58%) and caryophyllene oxide (8,54%). EOCS 13 showed bicyclogermacrene (16,29%), -phellandrene (15,42%) and -caryophyllene (13,82%) as main compounds. These samples demonstrated antispasmodic effect on preparations contracted with potassium (K+) and acetylcholine (Ach). EOCs 21 increased basal tonus and enhanced K+ induced-contraction in low concentrations. EOCs 13 elicited miorrelaxant effect on basal tonus and antispasmodic effect on K+ and Ach induced-contractions (IC50 = 45,51 7,58 g/ml and 404,29 99,93 g/ml, respectively). The effect on basal tonus appears to be epithelium-dependent. EOCs 13 also enhanced Ach-induced contractions upon extracellular Ca2+ removal. These results show that EOCs is able to relax isolated trachea and to inhibit contractions induced by receptor-dependent an independent mechanisms, wich demonstrate its antispasmodic effect. This study suggests that the relaxing effects of EOCs may involve the blockage of L-type Ca2+ channels and that EOCs maybe alter the storage of Ca2+ from the internal compartments.

ASSUNTO(S)

croton sonderianus óleos essenciais músculo liso traqueal contratilidade fisiologia croton sonderianus essential oils tracheal smooth muscle contractile responses.

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