Efeito do paricalcitol e do calcitriol sobre a doença cardiovascular em camundongos uninefrectomizados ApoE -/- / Effect of paricalcitol and calcitriol on cardiovascular disease in uninephrectomized ApoE -/- mice

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The study investigated the influence of a 10-week treatment with Paricalcitol (0.1µg/kg, 5x/week) or Calcitriol (0.03µg/kg, 5x/week) on cardiovascular disease in spontaneously atherosclerotic ApoE -/- mice submitted to uninephrectomy (UNX). Results: capillary length density of the heart was significantly lower in UNX Control, but not in UNX Paricalcitol and UNX Calcitriol animals, when compared to shams. In the aortas, a significantly lower wall/lumen ratio was observed in the Sham Control group when compared to UNX Control and UNX Calcitriol groups. In the latter, vascular calcifications accompanied by a significant presence of Runx-2 (cbfa-1) positive cells was observed. TGFß aorta expression was significantly higher in UNX Control and UNX Calciriol groups when compared to UNX Paricalcitol. Conclusions: Both treatments were able to prevent the reduction in heart capillarization induced by the UNX model. Treatment with Calcitriol at the employed dose and duration, though, induced significant vascular calcifications.

ASSUNTO(S)

mönckeberg medial calcific calcitriol calcitriol aterosclerose esclerose calcificante da média vitamin d/analogues &derivatives atherosclerosis vitamina d/análogos &derivados

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