Efeito de um complexo homeopático no desempenho e no comportamento de camundongos sob estresse agudo / Effect of a homeopatic complex on the performance and behavior of mice under acute stress

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

To evaluate the effect of homeopathic commercial complex (Convert H) on the performance and behavior of mice (Mus musculus) submitted to acute stress, two colonies were used: a Colony Bioterio (animals that did not receive the product) and Colony Convert H (animals from mice receiving the product for 16 generations). The animals were randomly assigned into four groups organized in the 2X2 factorial, with the stress factor and factor homeopathy. The agent stressor employee was the immobilization of the animals for 60 minutes in mini pipes of PVC immediately before the start of the behavioral evidence. Body weight and food intake of the mice were measured between 21 (weaning), and 98 days of age. The behavioral assessments, made to 98 days of age, involving aspects associated with anxiety and mobility in evidence in the elevated plus-maze test, the spontaneous mobility in the open-field test and the aggressiveness in the resident-intruder paradigm. The animals of the Colony Convert H obtained lower (p=0.002) weight gain and a higher (p<0.0001) consumption of feed, which resulted in a worse (p<0.0001) feed. It was not identified interaction between the stresses caused acute and complex homeopathic on behavioral variables observed in the elevated plus-maze test and the open-field test. The animals responded to stress applied with less anxiety and less mobility spontaneous and there were no effect on the aggressiveness. The used complex had an anxiogenic effect on animals not submitted to the stressing agent, this effect which was already expected according to the pathogenesis in the product. In animals submitted to stress the anxiogenic effect of the complex was not expected, because under the stressing agent, there was also reduction of anxiety. The two groups that received homeopathy showed decreased motor activity, it is not possible to prove in this paper the response expected about reduction of the negative effects of stress on this behavior. The greater aggressiveness by the animals that received homeopathy, showing greater territoriality in defense of their environment, does not reveal the ability of the product to correct the unwanted effect of the stressing agent on this behavior, perhaps because the stress has not provoked in the animals of this work, significant effect on aggressiveness. We conclude that the complex pathogenesis homeopathic studied, that is, anxiety, small motor activity and aggressiveness, is also observed in mice.

ASSUNTO(S)

animais - efeito do stress agression medicamentos veterinários homeopatia veterinária weight gain animal production anxiety ganho de peso veterinary homeopathy producao animal

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