Efeito da tansulosina e do nifedipino na eliminação de fragmentos após litotripsia extracorpórea por ondas de choque em pacientes com cálculos renais: estudo prospectivo, duplo-cego e randomizado / Effect of tamsulosin and nifedipine on the clearance of fragments after extracorporeal shock waves lithotripsy in patients with kidney stones - a prospective, double-blind and randomized study
AUTOR(ES)
Fabio Carvalho Vicentini
DATA DE PUBLICAÇÃO
2011
RESUMO
Purpose: We evaluated the effects of the adjuvant use of tamsulosin and nifedipine after extracorporeal shock wave lithotripsy (SWL) for 5-20 mm kidney stones. Materials and Methods: We conducted a randomized double-blind trial involving 136 patients with radiopaque kidney stones between 2006 and 2009. Patients were divided into three groups to receive daily treatments of 0.4 mg tamsulosin, 20 mg nifedipine retard or placebo for up to 30 days after one session of SWL. The parameters assessed were success rate, analgesic requirements, pain intensity, time to clearance, adverse effects and occurrence of Steinstrasse. Results: The success rate was 60.5% (23 of 38) in the Tamsulosin group, 48.6% (17 of 35) in the Nifedipine group and 36.8% (14 of 38) in the Placebo group (p=0.118). For stones ranging from 10 to 20 mm, the success rates were significantly higher in the Tamsulosin (61.9%) and Nifedipine groups (60.0%) when compared with the Placebo group (26.1%) (p=0.024), but not for the 5-9 mm stones (p=0.128). The Number Needed to Treat was 2.9 for tamsulosin and 3 for nifedipine. Adverse events were more frequent in the Nifedipine than the Placebo Group (28.5% vs. 2.6%, respectively, p=0.009). There was no difference among groups with regard to stone and demographic characteristics, pain intensity, time to clearance and Steinstrasse. Conclusions: Adjuvant use of tamsulosin or nifedipine after SWL significantly increased the success rates for 10 to 20 mm renal stones and could be recommended. Both drugs had similar beneficial effects and adverse events
ASSUNTO(S)
adrenergic alpha-antagonists alfa-antagonistas adrenérgicos bloqueadores dos canais de cálcio calcium channel blockers cálculos renais kidney calculi lithotripsy litotripsia
Documentos Relacionados
- Análise química e morfológica de cálculos renais: estudo comparativo duplo-cego
- EFEITO DO CAMPO ELETROMAGNÉTICO PULSADO NA CONSOLIDAÇÃO DAS ARTRODESES POSTEROLATERAIS LOMBOSSACRAS: ESTUDO PROSPECTIVO, DUPLO-CEGO E RANDOMIZADO
- Uso ou não uso do torniquete na videoartroscopia do joelho: estudo clínico multicêntrico, prospectivo, duplo-cego e aleatório
- O uso de corticoesteróides após dilatação esofágica em pacientes portadores de estenose por substâncias corrosivas: estudo prospectivo, randomizado e duplo-cego
- Anestesia venosa total livre de opioides, com infusões de propofol, dexmedetomidina e lidocaína para colecistectomia laparoscópica: estudo prospectivo, randomizado e duplo-cego