Efeito da eritromicina, administrada por via oral, no tratamento de crianças com constipação intestinal cronica funcional

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Functional constipation is a common problem in pediatric practice. Clinical presentation varies among patients and so does treatment. Abdominal mass and soiling indicate severe constipation. Although the pathophysiology is unclear, probably constipated patients present an intestinal motility disturbance, thus, prokinetics agents could be use fui for whose one with severe disease. OBJECTIVE: This study aims to evaluate the value of erythromycin, a prokinetics agent, in addition to the usual therapy in constipated children. METHODS: The study has included fourteen school-aged constipated children who had palpable abdominal mass and soiling. Methodology was based in double blind, placebo-controlled crossover study. Six children have ingested erythromycin, 20rnglKg, orally, divided in 4 doses, during a month, and placebo in the following month (GROUP 1). Eight children have ingested placebo in the first month and erythromycin in the next one (GROUP 2). A score was elaborated to evaluate the clinical evolution. Such score included stool :fTequency, painful defecation, palpable fecal mass, soiling, fecal consistence and use of laxatives. The score was obtained in 0,15, 30, 45 and 60 days after the patients inc1usion in the study. RESULTS: There was no statistical difference between groups considering in initial score value, sex, age and symptoms duration (Mann- Whitney test p>0,05). Scores values for c1inical evolution was evaluated by statistical analysis ANOV A and they have pointed a significant improve during erythromycin ingestion. We conc1ude that erythromycin inc1usion in the treatment was benefic and presented no side effects. Erythromycin might act in the intestinal motility of children with severe functional constipation

ASSUNTO(S)

sistema gastrointestinal - motilidade

ACESSO AO ARTIGO

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