Dinâmica adaptativa, genealogias e testes estatísticos de neutralidade em evolução molecular / Adaptive dynamics, Genealogies and statistical tests of neutrality in molecular evolution
AUTOR(ES)
Leonardo Paulo Maia
DATA DE PUBLICAÇÃO
2004
RESUMO
This thesis discusses some topics of molecular evolution, extensively using generating function methods to find analytical results whenever possible. In first place, it gives the exact solution for the dynamics of an infinite population of infinitely long sequences (no back mutations) evolving under the action of deleterious mutations on either multiplicative or truncated fitness landscapes. In addition, the behavior of a population subject to successive dilutions of arbitrary intensity, just like some experimental evolution protocols, is found. The mathematical expressions, in principle, may prove useful in characterizing real populations of microor¬ganisms. It was also demonstrated that a generalized multidimensional branching process is a nice tool in numerically studying mutational degeneration effects (specifically a pheno¬menon called Mullers ratchet) in populations under a wide variety of exponential growth settings. Finally, the evolutionary history of finite populations was studied by simulations to probe the viability of certain statistic, like some topological measures in genealogical trees, being incorporated in statistical tests to detect the fingerprints of natural selection.
ASSUNTO(S)
testes de neutralidade mutation accumulation acúmulo de mutações muller s ratchet catraca de muller generating functions neutrality testes funções geradoras
