Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver
AUTOR(ES)
Dabeva, Mariana D.
FONTE
The National Academy of Sciences of the USA
RESUMO
The ability to identify, isolate, and transplant progenitor cells from solid tissues would greatly facilitate the treatment of diseases currently requiring whole organ transplantation. In this study, cell fractions enriched in candidate epithelial progenitor cells from the rat pancreas were isolated and transplanted into the liver of an inbred strain of Fischer rats. Using a dipeptidyl dipeptidase IV genetic marker system to follow the fate of transplanted cells in conjunction with albumin gene expression, we provide conclusive evidence that, after transplantation to the liver, epithelial progenitor cells from the pancreas differentiate into hepatocytes, express liver-specific proteins, and become fully integrated into the liver parenchymal structure. These studies demonstrate the presence of multipotent progenitor cells in the adult pancreas and establish a role for the liver microenvironment in the terminal differentiation of epithelial cells of foregut origin. They further suggest that such progenitor cells might be useful in studies of organ repopulation following acute or chronic liver injury.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23825Documentos Relacionados
- Differentiation of regenerating pancreatic cells into hepatocyte-like cells.
- Restoration of glucagon responsiveness in spontaneously transformed rat hepatocytes (RL-PR-C) by fusion with normal progenitor cells and rat liver plasma membranes.
- Retinoic acid induces differentiation of cochlear neural progenitor cells into hair cells
- Region-specific differentiation of neural tube-derived neuronal restricted progenitor cells after heterotopic transplantation
- Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes