Development of dissolution method for benznidazole tablets

AUTOR(ES)

Lima, Ádley Antonini Neves de, Soares Sobrinho, José Lamartine, Silva, Jeckson Luiz da, Corrêa Júnior, Roberto Antônio Cavadinha, Lyra, Magaly Andreza Marques, Rolim Neto, Pedro José

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2009

RESUMO

The aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\hydrochloride acid buffer pH 1.2 with stirring speed of 75 rpm, volume of 900 mL and paddle as apparatus. Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for benznidazole tablets.

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