Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules
AUTOR(ES)
Mendonça, Taciane Ferreira, Barros, Eliézer Giannini de, Pereira, Gislaine Ribeiro, Araújo, Magali Benjamim de, Bonfilio, Rudy
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2011
RESUMO
This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution medium and paddle as the apparatus at 50 rpm. The drug concentrations in the dissolution media were determined by UV spectrophotometry and HPLC and a statistical analysis revealed that there were significant differences between HPLC and spectrophotometry. This study illustrates the importance of an official method for the dissolution test, since there is no official monograph for diltiazem hydrochloride in capsules.
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