Desenvolvimento e validação de metodologia analítica para determinação de disruptores endócrinos resultantes de atividades antrópicas nas águas da região do Rio Paraíba do Sul,SP / Development and validation of analytical methodology for determination of endocrine disruptors from anthropic activities in waters at region of Paraíba do Sul river, SP

AUTOR(ES)

Renata Rodrigues de Souza

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

12/07/2011

RESUMO

The evaluation of six synthetics substances from industrials process and anthropogenic activities - diethyl phthalate, dibuthyl phthalate, nonylphenol, pentachlorophenol, bisphenol A and benzo[a]pyrene which one can interfer negatively in normal function of the endocrine system from animals and humans (xenoestrogens), was carried out in this study in drinking water and raw water on four cities at region of Paraíba do Sul River. An analytical method with high selectivity and sensitivity, with determination by gas chromatography coupled to mass spectrometry detector (GC/MS), preceded of samples concentration through the SPE technique was used. Good analytical techniques are not enough to ensure quality and reliability of the generated data results. For this, the methodology was submitted to the validation process, where parameters evaluated were: selectivity, specificity, linearity, work range, detection and quantification limits, precision, accuracy, robustness, percentage of recovery and uncertainty in measurement. The validation results showed that proposed method is suitable to quantify Paraíba do Sul river samples, and by its application could observe presence of all studied pollutants in drinking and raw water in one of the three sampling periods at least, and the highest measured concentrations were in raw water at dry periods. These results evidence that the anthropic activities at region are influencing the water quality of the studied water resource, as well as the quality of water for public supply.

ASSUNTO(S)

cromatografia gasosa disruptores endócrinos endocrine disruptors espectrometria de massas gas chromatography mass spectrometry method validation qualidade da água validação de metodologia water quality

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