Deletion of the Multiple-Drug Efflux Pump AcrAB in Escherichia coli Prolongs the Postantibiotic Effect

AUTOR(ES)

Stubbings, William

FONTE

American Society for Microbiology

RESUMO

The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established.

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