De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

AUTOR(ES)

Mashima, T

FONTE

Nature Publishing Group

RESUMO

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.

Documentos Relacionados

• FATTY-ACID METABOLISM BY HUMAN ADIPOSE TISSUES*
• Fatty-Acid composition of free-choice starter broiler diets
• Fatty-Acid composition of free-choice starter broiler diets
• Fatty-Acid Composition of Candida utilis as Affected by Growth Temperature and Dissolved-Oxygen Tension
• Regulation of Mammalian Fatty-Acid Synthetase. The Roles of Carbohydrate and Insulin