Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India
AUTOR(ES)
Kumaria, Rajni
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2010-04
RESUMO
The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and elucidate the prognostic markers among four dengue serotypes, this study was conducted on 320 inpatients having acute febrile illness clinically suspected as DI, over a period of five years. Dengue serotypes were confirmed by multiplex reverse transcriptase (RT)-PCR. Eighty patients were positive for DI with presence of Den-1, Den-2, Den-3, and Den-4 in 8, 35, 27 and 10 patients, respectively. The severe clinical manifestations, abdominal pain and hepatomegaly, were comparatively higher in Den-2 patients. Liver aminotransferases levels were also higher in Den-2 patients (app. 5 fold). This study clearly indicates the hyperendemicity of all dengue serotypes. Nucleotide sequencing of Envelope region revealed that the presently emerged Den-3 belongs to type III, having high homology with genotype responsible for number of outbreaks in 1980s. The re-emergence of this deadly type can be suspected to cause more outbreaks in future and is a matter of great concern.
Documentos Relacionados
- Dengue Disease Spectrum among Infants in the 2001 Dengue Epidemic in Chennai, Tamil Nadu, India
- Virological Interpretations of Dengue Disease Spectrum in Infants in Chennai, Tamil Nadu, India, Need Reevaluation
- Spectrum of clinical disease in a series of 135 hospitalised HIV-infected patients from north India
- A Population-based Study of Hospital Admission Incidence Rate and Bacterial Aetiology of Acute Lower Respiratory Infections in Children Aged Less Than Five Years in Bangladesh
- AmpC beta lactamases among Gram negative clinical isolates from a tertiary hospital, South India