Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I.
AUTOR(ES)
Ciminale, V
RESUMO
Novel cytoplasmic mRNA species produced by human T-cell leukemia virus type I (HTLV-I) were cloned by using the polymerase chain reaction technique. Five novel 3' splice sites located in the X region and upstream of the env gene were identified. Splicing to the 3' splice sites in the X region generates mRNAs that express two previously unidentified viral proteins, named Rof and Tof. Tof accumulates in the nucleoli of transfected cells. The other viruses of the HTLV family, such as HTLV-II and bovine leukemia virus, also have a complex splicing pattern and are capable of producing additional proteins encoded in the X region. These results suggest that HTLV-I and other members of the HTLV family produce novel proteins, which may contribute to the biological properties of these viruses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240923Documentos Relacionados
- Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.
- Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I.
- High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient.
- T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.
- Infection of human endothelial cells by human T-cell leukemia virus type I.