Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae
AUTOR(ES)
Tettelin, Hervé
FONTE
National Academy of Sciences
RESUMO
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=129455Documentos Relacionados
- Draft genome of the emerging pathogen, Kocuria marina, isolated from a wild urban rat
- Complete Genomic Sequence of SfV, a Serotype-Converting Temperate Bacteriophage of Shigella flexneri
- Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T†
- Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T
- Complete sequence and comparative analysis of the chloroplast genome of Plinia trunciflora