Comparação dos efeitos hemodinâmicos da efedrina ou da fenilefrina em eqüínos anestesiados com isoflurano / Comparison of hemodynamics effects of ephedrine or phenylephrine in horses anesthetised with isoflurane
AUTOR(ES)
Gabriela Gomes Marchioni
DATA DE PUBLICAÇÃO
2003
RESUMO
Depression of the cardiovascular system is a feature of the use of halogenated anesthetics in equine anesthesia. A decrease in tissue perfusion is the main result and can be the cause of complications such as post-anesthetic myopathy, ileus and renal insufficiency. The aim of then present study was to evaluate the hemodynamic effects of two sympathomimetic agents, ephedrine and phenylephrine in horses anesthetized with isoflurane, which presented hypotension during the anesthetic procedure. Ten healthy horses, in lateral recumbence, were randomly distributed in two groups of five animals each. Group I received an infusion of ephedrine (0.02mg/kg/min) and group II an infusion of phenylephrine (0.002mg/kg/min) and the surveyor did not know the agent administered. Hemodynamic, oxygenation and ventilation parameters were evaluated and the results submitted to statistical analysis performed by means of analysis of variance followed by the Tukey-Kramer and Student-T test. When the different moments of the same group were compared, an increment or maintenance of the hemodynamic parameters evaluated after the infusion of both agents was noticed. However, when the correspondent moments of each group were compared, the cardiac index, the mixed venous oxygen content, oxygen transport index and both mixed venous oxygen saturation and partial pressure were superior in group I. It was concluded that the two agents promoted the desired hemodynamic effects, although ephedrine caused the best cardiovascular and oxygenation responses. For this reason, we can presume that ephedrine infusion probably promotes superior tissue perfusion, and therefore is more indicated for the treatment of hypotension in horses submitted to general anesthesia.
ASSUNTO(S)
equine anesthesia hemodynamic eqüino anestesia hemodinâmica
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