Clinicopathological and immunohistochemical features of spindle cell carcinoma of the head and neck / Caracteristicas clinicopatologicas e imunohistoquimicas do carcinoma de celulas fusiformes de cabeça e pescoço

AUTOR(ES)

Mario Jose Romanach Gonzalez Sobrinho

DATA DE PUBLICAÇÃO

2008

RESUMO

Squamous cell carcinoma (SCC) is the most common malignant oral tumor and several uncommon clinicopathological variants, including spindle cell carcinoma (SpCC), which differ on clinical behaviour, diagnostic criteria and prognosis, have been described. The aims of this study were to analyze the immunohistochemical expression of epithelial markers on head and neck SpCC, evaluating their diagnostic relevance, to compare the histopathological and immunohistochemical features of head and neck SpCC and conventional oral SCC, and to define a socio-demographic and clinicopathological profile of oral SpCC. Material included a total of 20 cases, including 10 cases of head and neck SpCC, and 10 cases of oral SCC used as controls (5 well-differentiated SCC and 5 poorly-differentiated SCC). Methods included evaluation of hematoxilin and eosinstained histological slides from all cases through optic microscopy and immunohistochemical reactions for antibodies against cytokeratins, vimentin, desmin, smooth-muscle actin, muscle-specific actin, S-100 protein, EMA, p53 and ki-67, using the peroxidase technique. Morphological features of SpCC showed similarities to the features from poorly differentiated SSC and immunohistochemical expression of the cytokeratins AE1/AE3, 6, 8 and 14, and EMA on both carcinomatous and spindle cell components of the tumor, proved to be useful as an auxiliary tool on final diagnosis. In addition, SpCC presented higher p53 and ki-67 expression indexes when compared to well-differentiated SCC. Oral SpCC showed predilection for males on their 6th decade of life, presenting clinically either as painful infiltrative ulcers or ulcerated exophytic polypoid masses, preferally located on the alveolar mucosa and lips.

ASSUNTO(S)

immunohistochemistry carcinoma squamous cell carcinoma de celulas escamosas imunohistoquimica

Documentos Relacionados

• Avaliação clinicopatologica de condrossarcomas de cabeça e pescoço
• Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis
• Ação do Viscum album em cultivo celular de carcinoma epidermoide de cabeça e pescoço
• Estudo dos fatores prognosticos do carcinoma espinocelular de pele de cabeça e pescoço
• Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case