Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study

AUTOR(ES)

Andrade, Monica Coelho, Oliveira, Maria de Fatima, Nagao-Dias, Aparecida Tiemi, Coelho, Ivo Castelo Branco, Candido, Darlan da Silva, Freitas, Erlane Chaves, Coelho, Helena Lutescia Luna, Bezerra, Fernando Schemelzer Moraes

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

09/10/2013

RESUMO

Introduction The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. Methods A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. Results The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. Conclusions Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients.

Documentos Relacionados

• Trabeculectomy: a review and 4-year follow-up.
• Doping prevalence among preadolescent athletes: a 4‐year follow‐up
• Text messaging reminders to reduce non-attendance in chronic disease follow-up: a clinical trial
• Environmental epidemiology. IV. Chronic respiratory disease in an industrial town: a nine-year follow-up study. Preliminary report.
• Indirect pulp treatment in a permanent molar: case reort of 4-year follow-up