Clinical and biochemical alterations secondary to chronic unpredictable stress and oxidative stress in rats. / Alterações clínicas e bioquímicas decorrentes do estresse crônico imprevisível e do estresse oxidativo em ratos.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The study of stress effects in different animal models help to clarify signalization mechanisms involved in human diseases. The present project was divided in two parts. Firstly, we investigated the effects of chronic unpredictable stress (CUS) on the course of experimental autoimmune encephalomyelitis (EAE) and circulating corticosterone (CORT) concentrations. CUS aggravated the clinical signs of the disease in Lewis rats. However, plasma CORT during the development of clinical signs seemed to be solely dependent on the immunological challenge. Secondly, we investigated the oxidative and defense mechanisms in several CNS regions of rats submitted to an intestinal ischemia-reperfusion model. There were distinct results, as tissue analysis, in genic expression of NOS and COX, calcium-dependent nitric oxide synthase and arginase activities and TBARs content. Based on these results, we concluded that, at least during the first two hours of intestinal reperfusion, CNS lesions may be efficiently prevented by defense mechanisms able to modulate the oxidative injury.

ASSUNTO(S)

central nervous system encefalomielite animal animal encephalomyelitis ratos rats ischemia sistema nervoso central oxidative stress stress estresse isquemia estresse oxidativo

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