Chronic stress alters the immune response to influenza virus vaccine in older adults.
AUTOR(ES)
Kiecolt-Glaser, J K
RESUMO
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and socioeconomically matched control subjects. Caregivers showed a poorer antibody response following vaccination relative to control subjects as assessed by two independent methods, ELISA and hemagglutination inhibition. Caregivers also had lower levels of in vitro virus-specific-induced interleukin 2 levels and interleukin 1beta; interleukin 6 did not differ between groups. These data demonstrate that down-regulation of the immune response to influenza virus vaccination is associated with a chronic stressor in the elderly. These results could have implications for vulnerability to infection among older adults.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=39758Documentos Relacionados
- Neuraminidase-specific antibody responses to inactivated influenza virus vaccine in young and elderly adults.
- Enhancement of anti-influenza A virus cytotoxicity following influenza A virus vaccination in older, chronically ill adults.
- Assessment of Markers of the Cell-Mediated Immune Response after Influenza Virus Infection in Frail Older Adults
- Safety of and serum antibody response to cold-recombinant influenza A and inactivated trivalent influenza virus vaccines in older adults with chronic diseases.
- Cancer screening in older adults.