Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.
AUTOR(ES)
Tokino, T
RESUMO
The discovery that hepatitis B virus (HBV) integrates into host chromosomes raises the question of whether such viral DNA integration correlates directly with the activation of specific oncogenes or the inactivation of anti-oncogenes. To obtain insight into this problem, we randomly collected HBV integrant samples from different human hepatocellular carcinomas and identified the site of chromosomal integration by using in situ hybridization and/or linkage analysis with the flanking cellular DNAs as probes. Our findings did not specifically identify particular HBV DNA integration sites in chromosomes, although chromosomes 11 and 17 seemed to have more than the average number of integrants.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=250761Documentos Relacionados
- Hepatitis B virus infection and primary hepatocellular carcinoma.
- Hepatitis C virus replication in hepatocellular carcinoma.
- Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma.
- Myofibroblasts in hepatitis B related cirrhosis and hepatocellular carcinoma.
- Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma.