Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis
AUTOR(ES)
ul-Ain, Qurrat
FONTE
American Society for Microbiology
RESUMO
Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 μm) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=182631Documentos Relacionados
- Ketoprofen poly(lactide-co-glycolide) physical interaction
- Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine
- Population pharmacokinetic modeling of isoniazid, rifampin, and pyrazinamide.
- Preventive chemotherapy of tuberculosis in Cornell model mice with combinations of rifampin, isoniazid, and pyrazinamide.
- Formation of acylated growth hormone-releasing peptide-6 by poly(lactide-co-glycolide) and its biological activity
