Chemopreventive activity of geraniol and β-ionona when administrated alone or in combination during the promotion phase of hepatocarcinogenesis in rats. / Atividade quimiopreventiva do geraniol e β-ionona quando administrados isoladamente ou em associação a ratos durante a fase de promoção da hepatocarcinogênese

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Chemopreventive activities of β-ionone (BI) and geraniol (GR) were evaluated during promotion phase of hepatocarcinogenesis. Wistar rats received GR (25 mg/100 g body weight), BI (16 mg/100 g body weight), GR (25 mg/100 g body weight) +BI (16 mg/100 g body weight) or corn oil (CO, control). Multiplicity of hepatic nodules were smaller in BI group, compared to CO group. BI, GR and GR+BI groups presented decreased number of persistent preneoplastic lesions (PNL) and increased % of remodeling PNL. BI group presented decreased % liver section area occupied by persistent and remodeling PNL. GR group presented decreased % liver section area occupied by remodeling PNL. BI group tended to present reduced cholesterol concentration and inhibited cell proliferation. GR group increased number of apoptotic bodies in persistent PNL. BI and GR+BI groups reduced the % of remodeling and increased the % of persistent p53 positive PNL. RhoA protein in cellular membranes was reduced in GR group. Thus, BI and GR could be considered as chemopreventive agents against hepatocarcinogenesis.

ASSUNTO(S)

geraniol hepatocarcinogenesis alimentos naturais neoplasias produtos naturais chemoprevention geraniol hepatocarcinogênese natural products β-ionona β-ionona. quimioprevenção

ACESSO AO ARTIGO

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