Chemical mixture optimization with flexibility in the execution order of experiments / Otimização de misturas quimicas com flexibilidade na ordem de execução dos experimentos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

A split-plot statistical design is proposed for which the main-plots and sub-plots are both chemical mixture designs. Main-plots and sub-plots are investigated using the simplex-centroid design. The composite mixture-mixture design was applied to the simultaneous optimization of extractor solvents and mobile phases used in the chromatographic separation of chemical compounds from plant materials. The main goal was to determine the best response values, largest number of peaks, as a function of the extractor and mobiles phase components. The advantages of using blocked experiments following the split-plot structure is to minimize (or facilitate) the experimental work as well as reduce the chemical residuals that must be discarded or both. The drawback is that the statistical treatment of the system becomes more complex than designs with random schemes. Normals graphs were utilized for choosing models so, the realization of replicate experiments could be avoided

ASSUNTO(S)

otimização planejamento de experimentos split-plot split-plot optimization experimental designs

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