Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity

AUTOR(ES)

Kim, Ki Hyun, Moon, Eunjung, Lee, Seoung Rak, Park, Kyoung Jin, Kim, Sun Yeou, Choi, Sang Un, Lee, Kang Ro

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-11

RESUMO

As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 μM. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 μM).

Documentos Relacionados

• Evaluation of the physiological potential of radish seeds (Raphanus sativus L.)
• Adenosine Phosphates in Germinating Radish (Raphanus sativus L.) Seeds 1
• Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
• Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity
• Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity