Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity

AUTOR(ES)

Calixto, Nivea O., Cordeiro, Millena S., Giorno, Thais B. S., Oliveira, Gibson G., Lopes, Norberto P., Fernandes, Patricia D., Pinto, Angelo C., Rezende, Claudia M.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2017-05

RESUMO

Through dereplication strategies using gas chromatography-mass spectrometry (GC-MS) and ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS), the ethanol extract from Psycotria nemorosa leaves (Rubiaceae) showed to be composed of: cinnamic acid, dihydroactinidiolide, 4-hydroxy-β-ionone, phytol, isophytol, 4,8,12,16-tetramethylheptadecan-4-olide, lupeol, a mixture of α/β-amyrin, the keto and acetylated derivatives, besides stigmast-4-en-3-one, campesterol, stigmasterol and γ-sitosterol by GC-MS. Likewise, by UFLC-MS/MS, the main compounds identified were: butin, resveratrol, rutin, kaempferol 7-O-β-D-glucopyranoside, deacetylasperuloside, epiloganin, hordenine, strictosidine, N-methyl-1,2,3,4-tetrahydro-β-carboline and N-formyl-tryptamine. The antinociceptive activity of the crude extract ant its fractions was reported.

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