Characterization of Pseudomonas cepacia isolates from patients with cystic fibrosis.

AUTOR(ES)

McKevitt, A I

RESUMO

Pseudomonas cepacia infections which follow a fulminant course and which include septicemia are being reported with increasing frequency from cystic fibrosis patients. Forty-eight P. cepacia isolates from cystic fibrosis patients were screened for production of potential virulence factors. A majority of strains tested produced protease and lipase. Eleven strains harbored plasmids of approximate molecular weights in the range 50 X 10(6) to 100 X 10(6). Twenty-two strains produced a smooth lipopolysaccharide. Studies are presently under way to determine the role of these potential virulence factors in the pathogenesis of P. cepacia disease.

Documentos Relacionados

• Airborne dissemination of Burkholderia (Pseudomonas) cepacia from adult patients with cystic fibrosis.
• Pseudomonas cepacia in cystic fibrosis.
• Protease production by Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
• Identification of the mucin-binding adhesin of Pseudomonas cepacia isolated from patients with cystic fibrosis.
• Genotypic characterization of sequential Aspergillus fumigatus isolates from patients with cystic fibrosis.