Cervical papillomaviruses segregate within morphologically distinct precancerous lesions.
AUTOR(ES)
Crum, C P
RESUMO
We combined molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix to correlate the presence of certain strains of human papillomaviruses (HPVs) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPVs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254851Documentos Relacionados
- Oncogenic human papillomaviruses and ploidy in cervical lesions.
- p53 protein accumulation in oesophageal squamous cell carcinomas and precancerous lesions.
- Corneal elastosis within lattice dystrophy lesions.
- Calcification of umbilical artery: two distinct lesions.
- Proliferation in the normal cervix and in preinvasive cervical lesions.