"Células-tronco foliculares na alopecia difusa não-cicatricial de pacientes HIV positivos" / Hair follicle stem cells in diffuse non-cicatricial alopecia in HIV-1 positive patients
AUTOR(ES)
Carlos Baptista Barcaui
DATA DE PUBLICAÇÃO
2005
RESUMO
Seven percent of HIV positive patients present diffuse non-cicatricial alopecia (DNCA). The aim of this study was to compare the histological and the immunohistochemical (cytokeratin 19/TUNEL and cleaved caspase 3) findings in transverse scalp sections of 15 HIV-1 positive patients with DNCA and 12 healthy controls. Follicular stem and transit amplifying cells apoptosis in the bulge was demonstrated by double labeling TUNEL/CK19 in 80% of cases and 25% of controls, and by the anti-cleaved caspase 3 antibody in 61% of cases and 16% of the controls. There was no relation between the incidence of apoptosis and the degree of immunodeficiency among cases
ASSUNTO(S)
alopecia alopecia folículo piloso hiv hiv stem cells células-tronco hair follicle
