Cell-mediated resistance to infection with Listeria monocytogenes in nude mice.
AUTOR(ES)
Emmerling, P
RESUMO
Congenitally dysthymic nude (nu/nu) NMRI mice showed increased resistance to viable Listeria monocytogenes cells during the initial phase of infection as compared with euthymic control mice. The intravenous mean lethal dose (LD50), as determined for euthymic mice after an observation time of 7 and 14 days, amounted consistently to 6 X 10(4) Listeria. The corresponding values determined in nude mice were found to be increased by either 20-fold (1.2 X 10(6) Listeria after an observation time of 7 days) or 4-fold (2.4 X 10(5) Listeria after an observation time of 14 days). The transfer of spleen cells from immune euthymic donor mice into chronically infected nude mice caused almost complete elimination of Listeria within 1 week. The injection of dextran sulfate 24 h before a secondary infection with L. monocytogenes caused loss of antibacterial resistance in both chronically infected nude mice and Listeria-immune euthymic mice, this being expressed by a rapid increase in the numbers of bacteria in the spleens as well as the occurrence of serious signs of illness.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=421378Documentos Relacionados
- Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice
- Cell-mediated immunity to Sendai virus infection in mice.
- Listeria monocytogenes infection in nude mice.
- Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice.
- Cell-mediated immune response to Salmonella typhimurium infection in mice: development of nonspecific bactericidal activity against Listeria monocytogenes.
