Catalytic asymmetric reactions for organic synthesis: The combined C—H activation/Cope rearrangement
AUTOR(ES)
Davies, Huw M. L.
FONTE
National Academy of Sciences
RESUMO
The development of new catalytic asymmetric reactions can lead to exciting new strategies for organic synthesis. This article describes the synthetic utility of the combined C—H activation/Cope rearrangement, achieved by dirhodium tetraprolinate-catalyzed reaction of vinyldiazoacetates with compounds containing allylic C—H bonds. The transformation is highly diastereoselective and enantioselective. The product distribution, however, is highly substrate dependent, the major side products being either direct C—H activation or cyclopropanation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=397407Documentos Relacionados
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